How is drug induced thrombocytopenia treated?

Treatment of DITP involves discontinuation of the offending drug. The platelet count usually starts to recover after 4 or 5 half-lives of the responsible drug or drug metabolite. High doses of intravenous immunoglobulin can be given to patients with severe thrombocytopenia and bleeding.

Does drug induced thrombocytopenia go away?

The expected course is that recovery of thrombocytopenia begins within 1 to 2 days after the drug is discontinued and recovery is usually complete within a week. Platelet transfusions may be necessary to control overt hemorrhage; corticosteroids are commonly used because the diagnosis of ITP cannot be excluded.

Which drug would be the most common cause of drug induced thrombocytopenia?

Heparin, a blood thinner, is the most common cause of drug-induced immune thrombocytopenia. If a medicine prevents your bone marrow from making enough platelets, the condition is called drug-induced nonimmune thrombocytopenia.

What is the first line treatment for ITP?

The standard initial treatment for ITP is oral corticosteroids to increase platelet counts. Intravenous immunoglobulin or anti-D immunoglobulin can also increase platelet counts and are particularly useful for stimulating rapid platelet increases before planned procedures.

Which antibiotics cause low platelets?

Some prescribed medications can also cause thrombocytopenia, including:

  • amiodarone.
  • ampicillin and other antibiotics.
  • cimetidine.
  • piperacillin.
  • seizure medications, such as carbamazepine.
  • sulfonamides, such as trimethoprim-sulfamethoxazole.
  • vancomycin.

When should you start treatment for ITP?

Recommendations for when to start initial treatment in children newly diagnosed with ITP are as follows: Any severe (grade 4) bleeding requires immediate hospital admission and treatment to increase platelet levels until bleeding has decreased.

Can dexamethasone increase platelets?

Dexamethasone (Decadron) is designed to increase the platelet count by slowing the destruction of platelets. Oral courses of highdose dexamethasone temporarily suppresses the body’s immune system so that it stops destroying platelets. Dexamethasone may help your bone marrow cells make more platelets.