What is bortezomib mechanism of action?

Mechanism of Action Bortezomib is a selective inhibitor of the 26S proteasome, preventing the activation of NF-κB. It induces apoptosis of rapidly dividing, metabolically active cells with extensive protein synthesis.

What is the role of bortezomib?

Bortezomib is used to treat people with multiple myeloma (a type of cancer of the bone marrow). Bortezomib is also used to treat people with mantle cell lymphoma (a fast-growing cancer that begins in the cells of the immune system). Bortezomib is in a class of medications called antineoplastic agents.

Who discovered bortezomib?

Discovery of Bortezomib Julian Adams and his team, who sought to inhibit the proteasome’s enzymatic functions in order to diminish the aberrant proteasome activity associated with cancer and inflammation [27–28].

What is carboplatin made of?

Chemistry. In terms of its structure, carboplatin differs from cisplatin in that it has a bidentate dicarboxylate (the ligand is CycloButane DiCarboxylic Acid, CBDCA) in place of the two chloride ligands, which are the leaving groups in cisplatin.

Is bortezomib a biologic?

Some intracellular peptides have been shown to be biologically active, and so the effect of bortezomib on the levels of intracellular peptides may contribute to the biological and/or side effects of the drug.

What type of drug is bortezomib?

Bortezomib is a type of cancer treatment drug called a proteasome inhibitor. Proteasomes are in cells.

What is the pH of carboplatin?

Carboplatin is a crystalline powder with the molecular formula of C6H12N2O4Pt and a molecular weight of 371.25. It is soluble in water at a rate of approximately 14 mg/mL, Approved v1.0 Page 2 2 of 21 and the pH of a 1% solution is 5 to 7. It is virtually insoluble in ethanol, acetone, and dimethylacetamide.

How is pemetrexed administered?

Pemetrexed injection comes as a solution (liquid) to be injected into a vein over 10 minutes. Pemetrexed injection is administered by a doctor or nurse in a medical office or infusion center. It is usually given once every 21 days.

Is bortezomib cytotoxic?

Bortezomib Bortezomib is a novel cytotoxic chemical entity that potently and specifically inhibits the proteolytic activity of the proteasome and thus the degradation of poly-ubiquitinated proteins destined for catalysis by the proteasome.