What is the idiosyncratic effect?
Idiosyncratic drug reactions may be defined as adverse effects that cannot be explained by the known mechanisms of action of the offending agent, do not occur at any dose in most patients, and develop mostly unpredictably in susceptible individuals only.
What causes idiosyncratic reaction?
Idiosyncratic Reactions Neoantigens may result from adducts formed from the interaction of reactive drug metabolites with cellular proteins. These neoantigens may be processed by Kupffer cells or other antigen-presenting cells, transported to the cell surface, and presented as antigens.
Which of the following is idiosyncratic ADR?
WHAT IS AN IDIOSYNCRATIC ADR? Idiosyncratic ADRs are unpredictable and difficult to prevent, if risk factors for occurrence are unknown. Idiosyncratic ADRs do not occur in most patients, may be unrelated to both the dose and the pharmacology of the drug, and can be potentially life-threatening.
What is idiosyncrasy in toxicology?
“Drug idiosyncrasy” refers to untoward reactions to drugs that occur in a small fraction of patients and have no obvious relationship to dose or duration of therapy. The liver is a frequent target for toxicity.
What does idiosyncratic mean in medical terms?
Idiosyncrasy is an abnormal reactivity to a chemical that is peculiar to a given individual. It could be: An abnormally exaggerated response, or an abnormal lack of response. A response unusual because it requires an unusually small or unusually large dose. An extension of the normal physiological drug effect.
What does idiosyncratic action mean?
What is idiosyncratic toxicity?
Idiosyncratic toxicity can occur when a convergence of risk factors, including drug exposure, tips the risk-benefit balance away from benefit and toward risk.
What is an idiosyncratic type?
Idiosyncratic means unique to an individual. Albert Einstein famously had lots of idiosyncratic habits. One thing that Einstein definitely wasn’t was an idiot. Yet idiosyncratic and idiot are related. Idio is ancient Greek for “one’s own.” An idiosyncratic person is someone who does things in his own way.
What is idiosyncratic belief?
The definition of idiosyncratic is quirky or peculiar, or the temperament which is unique to an individual. An example of an idiosyncratic person is someone who does a lot of out of the ordinary things. An example of an idiosyncratic trait is the way a person always deals with disappointment.
What does it mean if something is idiosyncratic?
Definition of idiosyncrasy 1a : a peculiarity of constitution or temperament : an individualizing characteristic or quality. b : individual hypersensitiveness (as to a drug or food) 2 : characteristic peculiarity (as of temperament) broadly : eccentricity.