What is propofol used for in veterinary medicine?
Propofol can be used for sedation, induction of anesthesia, and maintenance of anesthesia in small animal patients. In all these situations recovery from its effects is typically rapid and smooth.
How long is PropoFlo good for?
The opened vial should be placed in a covered container, held at room temperature and used within the allotted 28 day timeframe. Refrigeration is not recommended. Any unused propofol remaining at the end of 28 days should be discarded.
What PropoFlo 28?
PropoFlo and PropoFlo 28 are injectable medications for use in dogs for induction of anesthesia, for maintenance of general anesthesia for up to 20 minutes, or for induction of general anesthesia where maintenance is provided by inhalant anesthetics.
What is midazolam used for in dogs?
Midazolam, a benzodiazepine, is commonly used as a pre-anesthetic agent to provide sedation and muscle relaxation in dogs (1,2).
What are the side effects of propofol in animals?
The primary side effect of propofol is respiratory depression as evidenced by tachypnea and apnea. Tachypnea and apnea were observed in 43 and 26% of the cases in the clinical trial, respectively.
How do you get propofol out of your system?
When administered intravenously, propofol is rapidly cleared from the circulation. Its clearance takes place by redistribution possibly into the lungs and more importantly in the liver. Only 0.3% of the dose is excreted, unchanged, in the urine. The elimination half-life of propofol is approximately 0.5 h to 1.5 h.
How long does propofol take to wear off?
The half-life of elimination of propofol has been estimated to be between 2 and 24 hours. However, its duration of clinical effect is much shorter, because propofol is rapidly distributed into peripheral tissues. When used for IV sedation, a single dose of propofol typically wears off within minutes.
Can you refrigerate propofol?
Propofol is provided in a soybean oil and lecithin emulsion and should be handled with strict aseptic technique. The manufacturer states that propofol should not be refrigerated and, once opened, the contents should be used within 6 hours because of the high potential for significant bacterial contamination.
How many milligrams are in each milliliter of propofol?
Each ml of emulsion for injection/ infusion contains 10 mg of propofol. Sodium 0.035 mg.
How long does it take for midazolam to wear off?
Midazolam is the active ingredient in the brand-name Versed. Midazolam is characterized as a short-acting benzodiazepine. The half-life, which is how long it takes for half the drug to leave the system, is 1.5 to 2.5 hours.
Does the dose of propofol depend on the age of the animal?
In the presence of premedication, the dose of propofol may be reduced with increasing age of the animal. The dose of propofol should always be titrated against the response of the patient.
What are the side effects of propofol for dogs?
When using propofol, dogs should be continuously monitored and facilities for the maintenance of a patent airway, artificial ventilation, and oxygen supplementation must be immediately available. The primary side effect of propofol is respiratory depression as evidenced by tachypnea and apnea.
Does premedication affect the response to propofol?
As with other sedative hypnotic agents, the amount of opioid and/or α-2 agonist premedication will influence the response of the patient to an induction dose of propofol. In the presence of premedication, the dose of propofol may be reduced with increasing age of the animal.
What are the side effects of propofol (fluoxetine)?
The primary side effect of propofol is respiratory depression as evidenced by tachypnea and apnea. Tachypnea and apnea were observed in 43 and 26% of the cases in the clinical trial, respectively.