What class of drug is Phenindione?

Like coumarin derivatives, phenindione, a compound of the indandione class, acts by altering biosynthesis of coagulant proteins in the liver. It is used for preventing and treating thrombosis, thrombophlebitis, and thromboembolism.

What is Phenindione used for?

These medicines increase the time it takes for your blood to clot. Phenindione is used to prevent and treat blood clots in the veins and arteries, for example clots in the legs, lungs, brain or heart.

Is Dicumarol an anticoagulant?

Dicumarol is an coumarin-like compound found in sweet clover. It is used as an oral anticoagulant and acts by inhibiting the hepatic synthesis of vitamin K-dependent coagulation factors (prothrombin and factors VII, IX, and X).

What is difference between antiplatelet and anticoagulant?

Anticoagulants such as heparin or warfarin (also called Coumadin) slow down your body’s process of making clots. Antiplatelet drugs, such as aspirin, prevent blood cells called platelets from clumping together to form a clot.

Which vitamins antagonist is Dicoumarol?

Dicoumarol is an anticoagulant that acts as a vitamin K antagonist by inhibiting its bioavailability. While high doses of dicoumarol can result in uncontrolled bleeding, it has been utilized in therapeutic doses as an anticoagulant treatment for deep vein thrombosis and other blood clotting disorders.

What is the Iupac name of menadione?


Preferred IUPAC name 2-Methylnaphthalene-1,4-dione
Other names Menaphthone; Vitamin K3; β-Methyl-1,4-naphthoquinone; 2-Methyl-1,4-naphthodione; 2-Methyl-1,4-naphthoquinone
CAS Number 58-27-5

Is phenindione an anticoagulant?

An indandione that has been used as an anticoagulant. Phenindione has actions similar to warfarin, but it is now rarely employed because of its higher incidence of severe adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p234)

How does Phenindione thin the blood?

Phenindione thins the blood by antagonizing vitamin K which is required for the production of clotting factors in the liver. Anticoagulants such as Phenindione have no direct effect on an established thrombus, nor do they reverse ischemic tissue damage (damage caused by an inadequate blood supply to an organ or part of the body).

What is the pharmacokinetics of prednisolone and prednisone?

The pharmacokinetics of these agents are extremely complex. Prednisolone is the active drug moiety while prednisone is both a pro-drug and inactive metabolite o … Clinical pharmacokinetics and pharmacodynamics of prednisolone and prednisone in solid organ transplantation Clin Pharmacokinet.

What is the difference between warfarin and phenindione?

Phenindione has actions similar to warfarin, but it is now rarely employed because of its higer incidence of severe adverse effects. Phenindione inhibits vitamin K reductase, resulting in depletion of the reduced form of vitamin K (vitamin KH2).