Are lymphoid follicles normal?

Lymphoid follicles are a normal component of gut-associated lymphatic tissue. They are aggregates of lymphocytes surrounding germinal centers that straddle the muscularis mucosae.

What is lymphoid follicle?

Lymphoid follicles are small masses of tissues that contain aggregations of inflammatory cells, mainly B cells with some T cells and dendritic cells.

What happens in the lymphoid follicles?

Mature lymphoid follicles may contain high endothelial venules (HEV), follicular dendritic cells (FDC) and germinal centres with the potential to produce plasma cells and antibody responses against bacteria and/or auto-antigens, such as breakdown fragments from the extracellular matrix (ECM).

Does lymphoid aggregates mean cancer?

Unless otherwise stated, when composed of primary or secondary follicles, there are no features worrisome for lymphoma. Atypical lymphoid aggregate: A lymphoid aggregate that lacks the typical morphologic and immunophenotypic features of a reactive lymphoid aggregate but is not diagnostic of lymphoma.

What causes lymphoid hyperplasia?

Lymphoid hyperplasia is an increase in the number of normal cells (called lymphocytes) that are contained in lymph nodes. This most often happens when there is an infection with bacteria, viruses, or other types of germs and is part of the body’s reaction to the infection.

Does the spleen have follicles?

lymphocytes, and lymphatic nodules, called follicles in the spleen. Germinal centres in the white pulp serve as the sites of lymphocyte production. Similar to the lymph nodes, the spleen reacts to microorganisms and other antigens that reach the bloodstream by releasing special phagocytic cells known as macrophages.

Does the thymus have lymphoid follicles?

It is well-known that lymphoid follicles are observed in the normal and diseased human thymus. The lymphoid follicles are not different from those in lymph nodes, have germinal centers, and contain both dendritic cells and B lymphocytes, which are present in scant numbers in the normal human thy- mus (2, 7).

What causes lymphoid aggregates?

Lymphoid polyps (present in 15% of patients) are hyperplastic submucosal lymphoid aggregates, most likely due to a nonspecific infection (exposure to bacteria and viruses). Submucosal lymphoid tissue is prominent in children, particularly in the distal ileum (Peyer patches).

Are lymphoid aggregates normal in Colon?

Under normal conditions, the colorectal mucosa exhibits small numbers of scattered lymphocytes and plasma cells in the lamina propria and only few mucosal lymphoid aggregates (MLAs). In Crohn’s colitis, the number of lymphocytes and plasma cells in the lamina propria and of MLA is substantially increased.

What is lymphoid hyperplasia symptoms?

Nodular lymphoid hyperplasia generally presents as an asymptomatic disease, but it may cause gastrointestinal symptoms like abdominal pain, chronic diarrhea, bleeding or intestinal obstruction. A diagnosis is made at endoscopy or contrast barium studies and should be confirmed by histology.

What kind of lymphoid organ is spleen?

The spleen is the largest lymphatic organ in the body. Surrounded by a connective tissue capsule, which extends inward to divide the organ into lobules, the spleen consists of two types of tissue called white pulp and red pulp. The white pulp is lymphatic tissue consisting mainly of lymphocytes around arteries.

Do I have reactive lymphoid hyperplasia of the terminal ileum?

Ok, it seems like you have reactive lymphoid hyperplasia of the terminal ileum associated with the BCL2 and Ki67 biomarkers, as you mentioned. Lymphoid follicles with active germ centers are a unique sign of this benign condition of the terminal ileum.

What is terminal ileum inflammation (Ti)?

Chronic inflammation in the terminal ileum (TI) suggests a cause for the patient’s symptoms, especially when the clinical suspicion is Crohn’s disease (CD).

What does lymphoid follicles with active germinal centers mean?

Ask Your Own Question. This is a brief description of “prominent lymphoid follicles with active germinal centers” and is describing lymphoid hyperplasia. This normally happens when you are fighting an infection and your lymph nodes start producing more cells, tissue, and lymphocytes to help rid the infection.

What does a colonic lymphoid nodule look like?

These nodules may present in the stomach, small intestine (terminal ileum is the most common), and colon/rectum. Colonic lymphoid nodules may appear as red macules, as a circumferential target lesions (halo sign), or as raised papules[56,57].