Which MHC is self?

Which MHC is self?

Under steady-state conditions, cell surface major histocompatibility complex (MHC) I molecules are associated with self-peptides collectively referred to as the self-MHC I immunopeptidome (SMII). The SMII regulates all key events that occur during the lifetime of CD8 T cells in the thymus and in the periphery.

Is MHC a self marker?

These cell surface proteins are called MHC molecules. The presented self-antigens prevent an organism’s immune system from targeting its own cells. The presentation of pathogen-derived proteins results in the elimination of the infected cell by the immune system.

What is self MHC peptide?

These peptides are generated by proteolytic degradation of self or foreign proteins within cells expressing MHC class I or II molecules in a process known as antigen presentation [1]. Similarly, autoimmunity can be triggered by viral or bacterial peptides that mimic self-peptides [5,6].

Which cells have MHC I and MHC II?

MHC I are found on all nucleated body cells, and MHC II are found on macrophages, dendritic cells, and B cells (along with MHC I).

What MHC independent?

MHC-Independent TCRs Recognize Native Ligands Without Antigen Processing. Because antibodies bind to conformational epitopes on native proteins, blockade of T-hybridoma reactivity by ligand-specific antibodies suggests that their MHC-independent TCRs recognize native protein ligands.

Does MHC present self peptides?

MHC molecules present self and foreign peptides as well as mutated self peptides.

Do all cells express MHC class I?

Classical MHC class I molecules are ubiquitously expressed on all mammalian cells including cells of epithelial origin while MHC class II molecules are selectively expressed on antigen-presenting cells (APC) including dendritic cells (DC), macrophages, and B cells.

Do T cells express MHC?

Human T cells express major histocompatibility complex (MHC) class II antigens and adhesion molecules characteristic of antigen-presenting cells (APCs), and r~cent in vitro and in vivo evidence supports an antigen-pre- senting [unction for T cells.

What is self MHC restriction?

Definition of self MHC restriction; MHC restriction is the requirement that APC or target cells express MHC molecules that the T cell recognizes as self in order for T cell to respond to the antigen presented by that APC or target cell. (T cells will only recognize antigens presented by their own MHC molecules.)