What is topical thrombin used for?

THROMBIN-JMI is topical bovine thrombin indicated to aid hemostasis whenever oozing blood and minor bleeding from capillaries and small venules is accessible and control of bleeding by standard surgical techniques (such as suture, ligature, or cautery) is ineffective or impractical.

How do you administer thrombin?

For routine use, reconstitute THROMBIN-JMI with sterile isotonic saline at a recommended concentration of 1,000 to 2,000 International Units per mL. Where bleeding is profuse, as from abraded surfaces of liver or spleen, concentrations of 1,000 International Units per mL may be required.

Is thrombin a medication?

Thrombin is a protein that is produced naturally in the body. Recothrom® is a man-made protein produced to replicate the naturally occurring thrombin in the body. It is used to stop bleeding by helping the blood to clot. This medicine is to be given only by or under the supervision of your doctor.

Is used as topical anticoagulant?

Topical hemostats are used in the setting of surgery or trauma as adjuncts to maintain hemostasis. Topical hemostat products include gelatin sponges, collagens, fibrin sealants, and active thrombin preparations. These agents are applied locally to stop blood flow.

Which is used as topical anticoagulant?

Topical hemostat products include gelatin sponges, collagens, fibrin sealants, and active thrombin preparations. These agents are applied locally to stop blood flow.

What is the brand name for thrombin?

Thrombin is available under the following different brand names: Recothrom, Thrombogen, and Thrombin JMI.

What class of drug is thrombin?

Thrombin inhibitors are anticoagulants that bind to and inhibit the activity of thrombin therefore prevent blood clot formation. Thrombin inhibitors inactivate free thrombin and also the thrombin that is bound to fibrin. Thrombin inhibitors are used to prevent arterial and venous thrombosis.

Which drug is a direct thrombin inhibitor?

Currently, four parenteral direct inhibitors of thrombin activity are FDA-approved in North America: lepirudin, desirudin, bivalirudin and argatroban. Of the new oral DTIs, dabigatran etexilate is the most studied and promising of these agents.

What is Gelfoam and thrombin?

Absorbable Gelatin Sponge (Gelfoam). Gelfoam helps form a bulky artificial clot in vascular areas, as mentioned previously. It is usually wetted with thrombin or isotonic saline to allow pliability (saline) or greater clot formation (thrombin). It can be left in the surgical site and will be absorbed in 4 to 6 weeks.

Which chemical is used to stop bleeding?

Anhydrous aluminium sulfate is the main ingredient and acts as a vasoconstrictor in order to disable blood flow. The stick is applied directly to the bleeding site. The high ionic strength promotes flocculation of the blood, and the astringent chemical causes local vasoconstriction.

Why do pregnant women get nosebleeds?

Pregnant women are more likely to get nosebleeds due to increased blood volume, which may cause vessels in the nose to rupture. Pregnancy is full of quirky side effects – including nosebleeds. One in five patients get nosebleeds during pregnancy(epistaxis), compared with 6% of women who get them when not pregnant.

What if I am allergic to Thrombin-JMI epistaxis kit (thrombin)?

If you are allergic to Thrombin-JMI Epistaxis Kit (thrombin (topical)); any part of Thrombin-JMI Epistaxis Kit (thrombin (topical)); or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had. If you are allergic to beef products or hamsters. If you have very bad bleeding.

Can you get a tumor in your nose during pregnancy?

Approximately 5% of pregnant women develop pregnancy tumors, which typically form in the gums between the teeth but can also form in the nose. The masses can appear anywhere on the body and generally disappear after the baby is born. Treatment usually consists of either a medicated gel or nasal spray, which helps control bleeding.

How should I use thrombin?

Use thrombin (topical) as ordered by your doctor. Read all information given to you. Follow all instructions closely. Your doctor or other healthcare provider will put on the skin. This medicine must not be given as a shot. It can be deadly if given as a shot. Talk with the doctor.