What is Temgesic sublingual tablets used for?
TEMGESIC is a “pain killer”. It is used for the short term relief of severe pain. TEMGESIC belongs to a group of medicines called opioid (narcotic) analgesics. Opioid analgesics act directly on the brain and spinal cord to block the sensation of pain.
Why is buprenorphine given sublingually?
Buprenorphine, a partial agonist of mu opioid receptors approved for the treatment of tramadol dependence, is administered sublingually due to its extensive first-pass metabolism and resulting low oral bioavailability.
How do you take buprenorphine sublingual?
Use this medication as directed by your doctor, usually once daily. Place the medication under your tongue for 5 to 10 minutes and let it dissolve completely. If you are prescribed more than one tablet each day, you may place all of the tablets under your tongue at once or place two tablets at a time under your tongue.
Is Buprenorphine sublingual used for pain?
Buprenorphine oral/sublingual (given under the tongue) is used to treat opioid addiction. Other forms of buprenorphine are used to treat moderate to severe pain. Buprenorphine sublingual is not for use as a pain medication. Buprenorphine sublingual may also be used for purposes not listed in this medication guide.
How long do the effects of TEMGESIC last?
Buprenorphine reaches peak blood concentration levels in about 40 minutes to 3 1/2 hours. 3 Once you have taken a dose of the medication, the effects can last for up to 3 days.
Can I take TEMGESIC with paracetamol?
It’s safe to use buprenorphine with paracetamol, ibuprofen or aspirin. Do not take any painkillers with codeine including co-codamol, ibuprofen and codeine (Nurofen Plus) and Solpadeine when using buprenorphine – you will be more likely to get side effects.
Can you just swallow buprenorphine sublingual tablets?
This medicine comes as sublingual tablets or a sublingual film (thin sheet). Do not cut, chew, or swallow the tablets. The tablets will not work if chewed or swallowed and may cause withdrawal symptoms.
Is buprenorphine absorbed orally?
Buprenorphine is readily absorbed through the gastrointestinal and mucosal membranes. However, due to extensive first-pass metabolism, buprenorphine has very poor oral bioavailability (10% of the intravenous route) if swallowed.
What happens when you swallow buprenorphine?
Official Answer. While swallowing Subutex (buprenorphine) is unlikely to be harmful, it will reduce how much medicine your body takes in and make the medicine much less effective. Subutex is readily absorbed into your bloodstream through the gastrointestinal and mucosal membranes.
Can a sublingual tablet be swallowed?
Do not swallow a lozenge or sublingual tablet whole. Allow it to dissolve in your mouth without chewing. The sublingual tablet should be placed under your tongue. Do not crush, chew, or break an extended-release tablet.