What does salinomycin do?

What does salinomycin do?

Salinomycin kills cancer stem cells in different types of human cancers by interfering with ABC drug transporters, the Wnt/β-catenin signaling pathway, mitochondrial function and other cancer stem cell (CSC) pathways.

Is salinomycin antibiotic?

Salinomycin is an antibacterial and coccidiostat ionophore therapeutic drug.

What is coccidiostats in poultry?

Coccidiostats are compounds that are widely used as feed additives to prevent and treat coccidiosis, a contagious disease affecting mainly poultry, and which is associated with warm and humid conditions, as can be found on poultry farms.

What is Coccidiostat in poultry?

How does bacitracin zinc work?

This medication is used to prevent minor skin infections caused by small cuts, scrapes, or burns. Bacitracin works by stopping the growth of certain bacteria. It belongs to a class of drugs known as antibiotics. This antibiotic only prevents bacterial infections.

What is the function of coccidiostats?

Coccidiostats are antiprotozoal agents that act on coccidia parasites by inhibiting reproduction and retarding the development of the parasite in a host cell. They are most commonly used in poultry populations by addition in the feed at the authorized levels and observing the prescribed hygiene requirements.

Are coccidiostats antibiotics?

Because the US classifies coccidiostats as antibiotics, they are not used in these chains. European broiler farmers do not want measures that would not allow the use of coccidiostats in feed.

What is Coccidiostat used for?

Coccidiostats are used for the treatment and prevention of coccidiosis, a contagious amoebic disease (Eimeria spp.) affecting livestock, particularly poultry, throughout the world and in particular in warm, humid environments.

Is a Coccidiostat an antibiotic?

Coccidiostats are animal-only antimicrobials that are not classified as veterinary medicinal products and their usage is not linked to reduction in antibiotics.

Is bacitracin bacteriostatic or bactericidal?

Bacitracin is a mixture of several closely related cyclic polypeptide antibiotics that has both bacteriostatic and bactericidal properties depending on the concentration of the drug and the susceptibility of the microorganism.

Are coccidiostats ionophores?

Ionophore coccidiostats are defined as lipophilic chelating agents that transport cations across cell membranes, and this mechanism is not only efficient against coccidian, but it can act also against the mammalian cells.

What is the mechanism of action of salinomycin?

Salinomycin (Procoxacin), a polyether potassium ionophore antibiotic, selectively inhibits the growth of gram-positive bacteria. Salinomycin is a potent inhibitor of Wnt/β-catenin signaling, blocks Wnt-induced LRP6 phosphorylation.

Is salinomycin a solid liquid or gas?

IDENTIFICATION: Salinomycin has a solid crystalline form. It is not soluble in water. USE: Salinomycin is used as an antibiotic in poultry, cattle and sheep. EXPOSURE: Workers that use salinomycin may breathe in dust or have direct skin contact.

Is salinomycin a spiroketal moiety?

Salinomycin contains a unique tricyclic spiroketal moiety and the successful synthesis of the bis-spiroketal moieties of salinomycin1,2 and the related ionophore CP44,1613 (Figure 1) sparked her on-going fascination with the synthesis of bioactive spiroketal-containing natural products.

Is salinomycin toxic to humans?

RISK: Data on the potential for salinomycin to produce toxic effects in humans were not available. Salinomycin caused skin and eye irritation in laboratory animals. Damage to muscles and nerves, paralysis, weakness, heart failure, and death have been observed in farm animals following accidental salinomycin poisoning.

https://www.youtube.com/watch?v=qyFIT9TF9eg