What does low IgG4 mean?

What does low IgG4 mean?

Low serum IgG4 concentrations are insufficient to fight with complement activators such as IgG1 and IgG3 and fail to block the binding of antigen and harmful autoantibodies, thereby causing autoimmune diseases.

What does an IgA deficiency mean?

Having an IgA deficiency means that you have low levels of or no IgA in your blood. IgA is found in mucous membranes, mainly in the respiratory and digestive tracts. It is also found saliva, tears, and breastmilk. A deficiency seems to play a part in asthma and allergies.

What is selective deficiency of IgG?

A person is considered to have a selective IgG subclass deficiency if blood levels of one or more of the IgG subclasses are below the normal range based on age, and if the levels of other immunoglobulins (total IgG, IgA, and IgM) are normal or near normal.

What diseases cause low IgG?

Infections that most often affect people with IgG deficiency are:

• Sinus infections and other respiratory infections.
• Gastrointestinal infections.
• Ear infections.
• Pneumonia.
• Bronchitis.
• Infections that result in a sore throat.
• Rarely, severe and life-threatening infections.

Is IgA deficiency life threatening?

In rare cases, people with selective IgA deficiency can develop a life-threatening condition called anaphylaxis (severe allergic reaction) if a doctor gives them blood products containing IgA.

What is the treatment for IgG deficiency?

Currently, the accepted therapy for IgG deficiency is the intravenous administration of 300-600 mg/kg of IgG once every 3-4 weeks, or 100-200 mg/kg/wk subcutaneously. Higher doses have been shown to be more effective in reducing infections in patients with histories of chronic or recurrent sinopulmonary infections.

What are the symptoms of immune deficiency?

Symptoms

• Frequent and recurrent pneumonia, bronchitis, sinus infections, ear infections, meningitis or skin infections.
• Inflammation and infection of internal organs.
• Blood disorders, such as low platelet counts or anemia.
• Digestive problems, such as cramping, loss of appetite, nausea and diarrhea.

Medical Care. Currently, the accepted therapy for IgG deficiency is the intravenous administration of 300-600 mg/kg of IgG once every 3-4 weeks, or 100-200 mg/kg/wk subcutaneously. [31] Higher doses have been shown to be more effective in reducing infections in patients with histories of chronic or recurrent sinopulmonary infections.

What causes IgG deficiency?

Researchers don’t know what causes primary IgG deficiency, but genetics may play a role. Secondary IgG deficiency may be caused by aging, malnutrition, medicines such as chemotherapy, and infections such as HIV.

What does IgG deficiency mean?

An IgG deficiency is a health problem in which your body doesn’t make enough Immunoglobulin G (IgG). People with IgG deficiency are more likely to get infections. When your body feels it is under attack, it makes special proteins called immunoglobulins or antibodies. These antibodies are made by the plasma cells.

What does IgG and IgM indicate?

IgM indicates the current infection. Immunology test indicates the recent or past occurrence of the infection. Both (IgM) and (IgG) are types of immunoglobulin proteins found in the immune system to fight against infections.