Is giant cell tumor aggressive?

A giant cell tumor is a rare, aggressive non-cancerous tumor. It usually develops near a joint at the end of the bone. Most occur in the long bones of the legs and arms. Giant cell tumors most often occur in young adults when skeletal bone growth is complete.

What percentage of giant cell tumor is malignant?

We identified 4 large series of patients with malignant giant cell tumor of bone that provided data on 2315 patients with giant cell tumor of bone. Across these studies, the cumulative incidence of malignancy was 4.0%; the cumulative incidence of primary malignancy was 1.6% compared with 2.4% for secondary malignancy.

Is giant cell tumor malignant?

Most giant cell tumors occur at the ends of the long bones of the arms and legs, near a joint (such as the knee, wrist, hip, or shoulder). Most are benign (not cancer) but some are malignant (cancer). Giant cell tumors usually occur in young and middle-aged adults. Also called GCT.

How fast does giant cell tumor grow?

Giant cell tumor of bone (GCTB) in skeletally immature patients is rare, and little is known regarding how fast GCTB can grow. We report a case of a 10-year-old skeletally immature girl with pathologically proven GCTB with obvious growth plate invasion that showed surprisingly rapid growth over only 14 days.

How do you get rid of a giant cell tumor of the tendon sheath?

Often, partial excision of the joint capsule or tendon sheath is necessary for complete removal of the tumor. Meticulous dissection and exploration are essential because satellite lesions are common.

How often do giant cell tumors come back?

For most cases, the postoperative recurrence could be observed within 24 months after the surgery. Depending on the type of surgical procedure and local presentation of the tumor, the recurrence rate of GCTB could range from 2.5% to 45% [5], [6].

How do you get rid of a giant cell tumor?

How is a giant cell tumor treated?

  1. Surgery to remove the tumor and any damaged bone.
  2. Bone grafting.
  3. Bone reconstruction.
  4. Physical therapy to regain strength and mobility.
  5. Amputation, in severe cases.

Do giant cell tumors metastasize?

Giant cell tumors of the bone are benign but locally aggressive, and they rarely metastasize to the lungs. The purpose of this study was to retrospectively review the clinical presentation, long-term outcomes, and treatment of pulmonary metastasis of these tumors.