What is N methyl 2 pyrrolidone used for?

N-Methylpyrrolidone (NMP) is a solvent used in a variety of industries and applications, such as paint and coating removal, petrochemical processing, engineering plastics coatings, agricultural chemicals, electronic cleaning and industrial/domestic cleaning.

Is NMP banned?

The U.S. Environmental Protection Agency (EPA) describes NMP as a developmental toxicant. In 2017, EPA proposed to ban this chemical’s use in paint stripping but then shelved the proposal under pressure from industry and in 2021 officially withdrew the proposal.

How do I remove NMP solvent?

Centrifugal evaporators that can remove NMP are available, however they are expensive and no system, can remove 100% of any solvent. Removing NMP under vacuum requires a good, oil free vacuum pump of the scroll style, a diaphragm pump is not strong enough, a cold trap with sub zero cabability, and a heated system.

Is NMP soluble in water?

N-Methyl-2-Pyrrolidone (NMP) is a high boiling, polar aprotic, low viscosity liquid. NMP has a good solvency for a wide range of organic and inorganic compounds and it is miscible with water at all temperatures and has a high chemical and thermal stability.

How do you make methyl 2 pyrrolidone?

N-Methyl-2-pyrrolidone (NMP) is prepared by preparing a mixture comprising monomethylamine, dimethylamine and trimethylamine and ammonia in a first process step by reacting ammonia with methanol at elevated temperature in the presence of a catalyst, separating 10 off the ammonia, reacting the mixture comprising the …

How toxic is NMP?

NMP has a low potential for skin irritation and a moderate potential for eye irritation in rabbits. Repeated daily doses of 450 mg/kg body weight administered to the skin caused painful and severe haemorrhage and eschar formation in rabbits. There is no clear toxicity profile of NMP after multiple administration.


NMP is considered a volatile organic compound (VOC) and is a California Prop 65 substance.

How do you remove NMP from a reaction mixture?

You can try to extract your product from reaction mixture using low BP. solvent that has ability to dissolve your product then evaporate the solvent, or chose solvent to extract NMP from reaction mixture. Also you can use column chromatography for separation..

Is NMP conductive?

Typically EG and Ultra 2 grades of NMP are used for this market/application. It is used because of its high flashpoint, high solvency and low toxicity, it is water soluble with high electrical conductivity.

Is NMP carcinogenic?

EPA and other regulatory bodies have not classified NMP as to its carcinogenicity in humans.

Is NMP a hap?

NMP is not listed as a Hazardous Air Pollutant (HAP) under Section 112 of the Clean Air Act. NMP is not listed as a Hazardous Substance, Priority Pollutant or Toxic Pollutant under the Clean Water Act. NMP is listed under TSCA and is subject to reporting in the Toxics Release Inventory.

How do you extract DMSO compound?

To remove DMSO, a common method is to wash with water and extract with a lower boiling point organic solvent like DCM1. Other methods involve freeze drying (lyophilization) after water dilution or solid phase extraction (SPE).