What is hedgehog in Drosophila?

Hedgehog (Hh) is a secreted signaling protein that regulates the growth and patterning of many organs. First identified because of its roles in Drosophila embryonic and imaginal disc development, it is now understood to be essential to most organs in Drosophila and higher vertebrates.

What does Hedgehog pathway do?

The Hedgehog signaling pathway is a signaling pathway that transmits information to embryonic cells required for proper cell differentiation. Different parts of the embryo have different concentrations of hedgehog signaling proteins.

Why is it called hedgehog gene?

The gene was named as such by Robert Riddle, who was a postdoctoral fellow at the Tabin Lab, after his wife Betsy Wilder came home with a gaming magazine containing an advert for the Sonic the Hedgehog video game.

Is a hedgehog invertebrate or vertebrate?

There are three classes of vertebrate hh genes: Sonic hedgehog, Indian hedgehog, and Desert hedgehog, with most vertebrate species possessing one member from each gene family. Mammals, including humans, and birds have one gene from each family: Sonic hh (Shh), Indian hh (Ihh), and Desert hh (Dhh).

What are pathway inhibitors?

13.4. Wnt pathway inhibitors are small molecules reported to induce differentiation of human embryonic stem cells into CMs, highlighting the role of this signaling pathway in cardiovascular development [72].

Is Sonic hedgehog a morphogen?

Sonic hedgehog (Shh), along with members of the Wnt and bone morphogenetic protein (BMP) families, is a molecule that acts early as a morphogen to determine neuronal fate and later as an axon guidance factor to help direct the paths of developing neurons (Figure 1).

What role does Sonic hedgehog gene have?

Normal Function The SHH gene provides instructions for making a protein called Sonic Hedgehog. This protein functions as a chemical signal that is essential for embryonic development. Sonic Hedgehog plays a role in cell growth, cell specialization, and the normal shaping (patterning) of the body.

How is the Hedgehog pathway regulated?

The Hedgehog (Hh) signal transduction pathway plays critical instructional roles during development. Ci is regulated through communication of the membrane proteins Patched (Ptc) and Smoothened (Smo) to the intracellular Hedgehog Signaling Complex (HSC) in response to a graded concentration of Hh ligand.

What do hedgehog proteins do?

The SHH gene provides instructions for making a protein called Sonic Hedgehog. This protein functions as a chemical signal that is essential for embryonic development. Sonic Hedgehog plays a role in cell growth, cell specialization, and the normal shaping (patterning) of the body.

How does the Hedgehog pathway antagonist 5E1 bind to Hedgehog?

Hedgehog pathway antagonist 5E1 binds hedgehog at the pseudo-active site. The Journal of biological chemistry 285.34 (2010 Aug 20): 26570-80. Cell type specific, traceable gene silencing for functional gene analysis during vertebrate neural development.

What is the hedgehog concept?

The Hedgehog Concept The Hedgehog Concept is developed in the book Good to Great. A simple, crystalline concept that flows from deep understanding about the intersection of three circles: 1) what you are deeply passionate about, 2) what you can be the best in the world at, and 3) what best drives your economic or resource engine.

Are two critical periods of Sonic hedgehog signaling required for motor neuron identity?

Two critical periods of Sonic Hedgehog signaling required for the specification of motor neuron identity. Cell 87.4 (1996 Nov 15): 661-73. Myo/Nog cell regulation of bone morphogenetic protein signaling in the blastocyst is essential for normal morphogenesis and striated muscle lineage specification.

Are there any sonic hedgehog hybridoma cells available?

Antigen: sonic hedgehog Hybridoma Cells Available: Yes Antigen Species: Rat Depositor: Jessell, T.M. / Brenner-Morton, S. Isotype: MIgG1 Antigen Additional Information: Also recognizes IHH (Indian Hedghog) PMID: 8662546 .