What is meant by divergent synthesis?
From Wikipedia, the free encyclopedia. In chemistry a divergent synthesis is a strategy with the aim to improve the efficiency of chemical synthesis. It is often an alternative to convergent synthesis or linear synthesis.
What is convergent and divergent synthesis?
In a divergent synthesis you make several compounds from a common intermediate. In convergent synthesis you make one larger molecule by bringing together the products of several routes.
Are dendrimers biocompatible?
PEG-terminated poly(aryl ether) dendrimers were found to be biocompatible nanodevices and can effectively encapsulate hydrophobic anticancer drugs204 (Fig.
What is meant by convergent synthesis?
In chemistry a convergent synthesis is a strategy that aims to improve the efficiency of multistep synthesis, most often in organic synthesis. Convergent synthesis is applied in the synthesis of complex molecules and involves fragment coupling and independent synthesis.
What are dendrimers made up of?
Dendrimers are nano-sized, radially symmetric molecules with well-defined, homogeneous, and monodisperse structure consisting of tree-like arms or branches [1]. Dendrimers are nearly monodisperse macromolecules that contain symmetric branching units built around a small molecule or a linear polymer core [5-7].
Are dendrimers safe?
Due to certain properties such as nanoscale size, a high degree of branching, polyvalency, biocompatibility, high water solubility, absence of immunogenicity, precise molecular weight, and available internal cavities, dendrimers are excellent vehicles for safely and effectively transporting drugs [11].
What are Synthons and synthetic equivalents?
The key difference between synthon and synthetic equivalent is that synthon is a moiety of a chemical compound that can be formed by a known synthetic process, whereas synthetic equivalent is a reagent that carries out the function of a synthon.
What is meant by synthon?
In retrosynthetic analysis, a synthon is a hypothetical unit within a target molecule that represents a potential starting reagent in the retroactive synthesis of that target molecule. The term was coined in 1967 by E. J. Corey.
How are dendrimers synthesized?
Dendrimers can be synthesized by two major approaches. In the divergent approach, used in early periods, the synthesis starts from the core of the dendrimer to which the arms are attached by adding building blocks in an exhaustive and step-wise manner.
What is divergent synthesis of PAMAM dendrimers?
The divergent synthesis of PAMAM dendrimers begins with an amine functional core unit which is reacted with methyl acrylate by Michael addition reaction. This yields the synthesis of two new branches per amine group with ester-terminated dendrimer, which is known as a “half-generation” dendrimer.
What is the difference between divergent synthesis and convergent synthesis?
Dendrimers are obtained either by divergent or convergent synthesis: that is, growth of the branched structure either starts from the core of the dendrimer to which the macromolecular branches are attached (divergent) or from the branches into the core (convergent).
Which class of dendrimers are used in drug delivery?
Probably the class of dendrimers that is most highly explored in drug delivery is the polyamidoamine (PAMAM) dendrimer. The divergent synthesis of PAMAM dendrimers begins with an amine functional core unit which is reacted with methyl acrylate by Michael addition reaction.