Can you take vitamins with orlistat?
Orlistat blocks your body’s absorption of some fat-soluble vitamins and beta carotene. Therefore, when you use orlistat you should take a daily multivitamin that contains vitamins A, D, E, K, and beta-carotene.
Which drug can reduce the absorption of fat-soluble vitamins?
Orlistat (Xenical, alli) and Olestra — Orlistat, a medication used for weight loss, and olestra, a substance added to certain food products, prevent the absorption of fat and can reduce the body’s absorption of fat-soluble vitamins.
Does orlistat cause vitamin deficiency?
However, prolonged use of Orlistat might cause a fat-soluble vitamin deficiency [52] . … It had been reported that sibutramine would elevate blood pressure and the heart rate (Halford, 2006). Orlistat would cause gastrointestinal adverse reactions and vitamins deficiency (McDuffie et al., 2002) , etc.
What vitamins does Alli block?
If you eat a meal that contains no fat, then you don’t need a dose of Alli. If you take Alli with a high-fat meal, you will likely experience more-severe gastrointestinal side effects. Alli can reduce the absorption of fat-soluble nutrients, including beta carotene and vitamins A, D, E and K.
Do I need to take vitamins on orlistat?
Orlistat may potentially impair the absorption of fat-soluble vitamins (A, D, E and K). Your dietitian may recommend that you take a multivitamin and mineral supplement whilst taking Orlistat. It will need to be taken at least 2 hours after taking Orlistat or at bedtime.
What is the best way to absorb fat-soluble vitamins?
Take fat-soluble vitamins with a meal, as the body requires fat to properly absorb them. Fat-soluble vitamins build up in the body, increasing the risk of toxicity if you use supplements .
Why are fat-soluble vitamins toxic?
Fat-Soluble Vitamins. Fat-soluble vitamins are dissolved in fats. They are absorbed by fat globules that travel through the small intestines and distributed through the body in the bloodstream. Because fat-soluble vitamins are not readily excreted, they can accumulate to toxic levels if taken in excess.
How does orlistat metabolized?
Metabolism: Orlistat metabolism is primarily within the intestinal wall. Elimination: 95 to -97% of the medication is unabsorbed and gets excreted in feces.
Does orlistat affect vitamin K absorption in obese patients?
… There was a study on effects of Orlistat on fat-soluble vitamins in obese adolescents which showed that Orlistat causes non-significant reduction in vitamin K absorption. This study also showed that Orlistat causes a non-significant increase in prothrombin time (PT) [9].
How does orlistat work in the body?
Orlistat, a weight-loss agent with a novel mechanism of action, recently was approved by the Food and Drug Administration for the treatment of obesity. It inhibits gastric and pancreatic lipases in the lumen of the gastrointestinal tract to decrease systemic absorption of dietary fat.
What drugs interfere with vitamin D absorption?
Orlistat, a commonly used weight-loss drug and cholestyramine, a cholesterol lowering drug can reduce the absorption of vitamin D and other fat-soluble vitamins [59,60] Corticosteroids and epilepsy drugs Phenobarbital and dilantin interfere with the metabolism of vitamin d, reducing active levels [61, 62].