What does high-grade prostatic intraepithelial neoplasia mean?

HGPIN refers to proliferation of prostate glandular epithelial cells that display significant cytological atypia within the confines of prostatic ducts and acini. 2. It has been accepted as the main precursor lesion to invasive prostate carcinoma.

What is prostate intraepithelial neoplasia?

Prostatic intraepithelial neoplasia (PIN) is a condition “defined by neoplastic growth of epithelial cells within preexisting benign prostatic acini or ducts.”3 Because PIN satisfies almost all the requirements for a premalignant condition, high-grade PIN (HGPIN) is widely accepted as a precursor to prostate cancer.

Does a man with prostatic intraepithelial neoplasia have a high risk of prostate cancer?

High-grade prostatic intraepithelial neoplasia is considered the most likely precursor of prostatic carcinoma. The only method of detection is biopsy; prostatic intraepithelial neoplasia (PIN) does not significantly elevate serum prostate-specific antigen concentration and cannot be detected by ultra-sonography.

What does abnormal cells in prostate mean?

BPH stands for benign prostatic hyperplasia. Benign means “not cancer,” and hyperplasia means abnormal cell growth. The result is that the prostate becomes enlarged. BPH is not linked to cancer and does not increase your risk of getting prostate cancer—yet the symptoms for BPH and prostate cancer can be similar.

What is prostatic intraepithelial neoplasia (PIN)?

What is prostatic intraepithelial neoplasia (PIN)? In this condition, there are changes in how the prostate gland cells look under the microscope, but the abnormal cells don’t look like they are growing into other parts of the prostate (like cancer cells would).

How is benign prostatic hyperplasia diagnosed?

The condition is usually diagnosed either during a prostate biopsy or when prostate tissue is removed during transurethral resection of the prostate (TURP), a treatment for benign prostatic hyperplasia. Originally PIN was classified as grade I, II, or III, according to increasing degrees of abnormality.

Does high-grade PIN mean prostate cancer?

High-grade PIN is considered a pre-cancer of the prostate because it may turn into prostate cancer over time. Low-grade PIN in general should not be on a biopsy report, as it has no significance. If I have high-grade PIN, does that mean it will turn into prostate cancer? No.

What is intraductal carcinoma of the prostate?

What is intraductal carcinoma of the prostate? Intraductal carcinoma often represents high-grade prostate cancer that is growing into pre-existing prostate ducts. It is often seen next to high-grade prostate cancer. What does it mean if there is intraductal carcinoma on my biopsy in addition to high-grade regular prostate cancer?